Publications

Genetics and Cardiovascular Disease

  1.  Sen SK, Boelte KC, Barb JJ, Joehanes R, Zhao X, Cheng Q, Adams L, Teer JK, Accame DS, Chowdhury S, Singh LN; NISC Comparative Sequencing Program; CHARGE Consortium, Kavousi M, Peyser PA, Quigley L, Priel DL, Lau K, Kuhns DB, Yoshimura T, Johnson AD, Hwang SJ, Chen MY, Arai AE, Green ED, Mullikin JC, Kolodgie FD, O’Donnell CJ, Virmani R, Munson PJ, McVicar DW, Biesecker LG.  Integrative DNA, RNA, and protein evidence connects TREML4 to coronary artery calcification.  Am J Hum Genet. 2014 Jul 3;95(1):66-76. doi: 10.1016/j.ajhg.2014.06.003. Epub 2014 Jun 26. PMID: 24975946
  2. Tsukamoto K, Mani DR, Shi J, Zhang S, Haagensen DE, Otsuka F, Guan J, Smith JD, Weng W, Liao R, Kolodgie FD, Virmani R, Krieger M. Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease.  Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17023-8. doi: 10.1073/pnas.1315986110. Epub 2013 Sep 30.  PMID: 24082102
  3. Tao M, Yu P, Nguyen BT, Mizrahi B, Savion N, Kolodgie FD, Virmani R, Hao S, Ozaki CK, Schneiderman J. Locally applied leptin induces regional aortic wall degeneration preceding aneurysm formation in apolipoprotein E-deficient mice.  Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):311-20. doi: 10.1161/ATVBAHA.112.300543. Epub 2012 Dec 6.  PMID: 23220275
  4. Campbell IC, Weiss D, Suever JD, Virmani R, Veneziani A, Vito RP, Oshinski JN, Taylor WR. Biomechanical modeling and morphology analysis indicates plaque rupture due to mechanical failure unlikely in atherosclerosis-prone mice.  Am J Physiol Heart Circ Physiol. 2013 Feb 1;304(3):H473-86. doi: 10.1152/ajpheart.00620.2012. Epub 2012 Nov 30.  PMID: 23203971
  5. Saeed O, Otsuka F, Polavarapu R, Karmali V, Weiss D, Davis T, Rostad B, Pachura K, Adams L, Elliott J, Taylor WR, Narula J, Kolodgie F, Virmani R, Hong CC, Finn AV.  Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis.  Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):299-307. doi: 10.1161/ATVBAHA.111.240101. Epub 2011 Nov 17.  PMID: 22095982
  6. Arking DE, Junttila MJ, Goyette P, Huertas-Vazquez A, Eijgelsheim M, Blom MT, Newton-Cheh C, Reinier K, Teodorescu C, Uy-Evanado A, Carter-Monroe N, Kaikkonen KS, Kortelainen ML, Boucher G, Lagacé C, Moes A, Zhao X, Kolodgie F, Rivadeneira F, Hofman A, Witteman JC, Uitterlinden AG, Marsman RF, Pazoki R, Bardai A, Koster RW, Dehghan A, Hwang SJ, Bhatnagar P, Post W, Hilton G, Prineas RJ, Li M, Köttgen A, Ehret G, Boerwinkle E, Coresh J, Kao WH, Psaty BM, Tomaselli GF, Sotoodehnia N, Siscovick DS, Burke GL, Marbán E, Spooner PM, Cupples LA, Jui J, Gunson K, Kesäniemi YA, Wilde AA, Tardif JC, O’Donnell CJ, Bezzina CR, Virmani R, Stricker BH, Tan HL, Albert CM, Chakravarti A, Rioux JD, Huikuri HV, Chugh SS.  Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals.  PLoS Genet. 2011 Jun;7(6):e1002158. doi: 10.1371/journal.pgen.1002158. Epub 2011 Jun 30.  PMID: 21738491
  7. Zhang W, Baban B, Rojas M, Tofigh S, Virmani SK, Patel C, Behzadian MA, Romero MJ, Caldwell RW, Caldwell RB.  Arginase activity mediates retinal inflammation in endotoxin-induced uveitis.  Am J Pathol. 2009 Aug;175(2):891-902. doi: 10.2353/ajpath.2009.081115. Epub 2009 Jul 9.  PMID: 19590038
  8. Fu Z, Wang M, Gucek M, Zhang J, Wu J, Jiang L, Monticone RE, Khazan B, Telljohann R, Mattison J, Sheng S, Cole RN, Spinetti G, Pintus G, Liu L, Kolodgie FD, Virmani R, Spurgeon H, Ingram DK, Everett AD, Lakatta EG, Van Eyk JE.  Milk fat globule protein epidermal growth factor-8: a pivotal relay element within the angiotensin II and monocyte chemoattractant protein-1 signaling cascade mediating vascular smooth muscle cells invasion.  Circ Res. 2009 Jun 19;104(12):1337-46. doi: 10.1161/CIRCRESAHA.108.187088. Epub 2009 May 14.  PMID: 19443842
  9. Tavora F, Burke A, Li L, Franks TJ, Virmani R. Postmortem confirmation of Lyme carditis with polymerase chain reaction.  Cardiovasc Pathol. 2008 Mar-Apr;17(2):103-7. doi: 10.1016/j.carpath.2007.03.004. Epub 2007 May 11.  PMID: 18329555
  10. Lim WS, Timmins JM, Seimon TA, Sadler A, Kolodgie FD, Virmani R, Tabas I. Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo.  Circulation. 2008 Feb 19;117(7):940-51. doi: 10.1161/CIRCULATIONAHA.107.711275. Epub 2008 Jan 28. Erratum in: Circulation. 2008 Apr 1;117(13):e303.   PMID: 18227389
  11. Joner M, Farb A, Cheng Q, Finn AV, Acampado E, Burke AP, Skorija K, Creighton W, Kolodgie FD, Gold HK, Virmani R.  Pioglitazone inhibits in-stent restenosis in atherosclerotic rabbits by targeting transforming growth factor-beta and MCP-1.  Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):182-9. Epub 2006 Oct 26.  PMID: 17068283
  12. Isobe S, Tsimikas S, Zhou J, Fujimoto S, Sarai M, Branks MJ, Fujimoto A, Hofstra L, Reutelingsperger CP, Murohara T, Virmani R, Kolodgie FD, Narula N, Petrov A, Narula J. Noninvasive imaging of atherosclerotic lesions in apolipoprotein E-deficient and low-density-lipoprotein receptor-deficient mice with annexin A5.  J Nucl Med. 2006 Sep;47(9):1497-505.  PMID: 16954559
  13. Ladich E, Virmani R, Burke A.  Sudden cardiac death not related to coronary atherosclerosis.  Toxicol Pathol. 2006;34(1):52-7. Review.  PMID: 16507544
  14. Varga R, Eriksson M, Erdos MR, Olive M, Harten I, Kolodgie F, Capell BC, Cheng J, Faddah D, Perkins S, Avallone H, San H, Qu X, Ganesh S, Gordon LB, Virmani R, Wight TN, Nabel EG, Collins FS. Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome.  Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3250-5. Epub 2006 Feb 21. PMID: 16492728
  15. Creighton W, Virmani R, Kutys R, Burke A. Identification of novel missense mutations of cardiac ryanodine receptor gene in exercise-induced sudden death at autopsy.  J Mol Diagn. 2006 Feb;8(1):62-7.PMID: 16436635
  16. Burke A, Creighton W, Mont E, Li L, Hogan S, Kutys R, Fowler D, Virmani R. Role of SCN5A Y1102 polymorphism in sudden cardiac death in blacks. Circulation. 2005 Aug 9;112(6):798-802. Epub 2005 Aug 1.  PMID: 16061744
  17. Fischer JW, Steitz SA, Johnson PY, Burke A, Kolodgie F, Virmani R, Giachelli C, Wight TN. Decorin promotes aortic smooth muscle cell calcification and colocalizes to calcified regions in human atherosclerotic lesions.  Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2391-6. Epub 2004 Oct 7.  PMID: 15472131
  18. Morgan AR, Rerkasem K, Gallagher PJ, Zhang B, Morris GE, Calder PC, Grimble RF, Eriksson P, McPheat WL, Shearman CP, Ye S. Differences in matrix metalloproteinase-1 and matrix metalloproteinase-12 transcript levels among carotid atherosclerotic plaques with different histopathological characteristics. Stroke. 2004 Jun;35(6):1310-5. Epub 2004 Apr 8.  PMID: 15073384
  19. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W Jr, Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK, Willerson JT.  From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II.  Circulation. 2003 Oct 14;108(15):1772-8. Review.  PMID: 14557340
  20. Sperry JL, Deming CB, Bian C, Walinsky PL, Kass DA, Kolodgie FD, Virmani R, Kim AY, Rade JJ. Wall tension is a potent negative regulator of in vivo thrombomodulin expression.  Circ Res. 2003 Jan 10;92(1):41-7.  PMID: 12522119
  21. Kolodgie FD, Burke AP, Farb A, Weber DK, Kutys R, Wight TN, Virmani R. Differential accumulation of proteoglycans and hyaluronan in culprit lesions: insights into plaque erosion.  Arterioscler Thromb Vasc Biol. 2002 Oct 1;22(10):1642-8.  PMID: 12377743
  22. Kim AY, Walinsky PL, Kolodgie FD, Bian C, Sperry JL, Deming CB, Peck EA, Shake JG, Ang GB, Sohn RH, Esmon CT, Virmani R, Stuart RS, Rade JJ. Early loss of thrombomodulin expression impairs vein graft thromboresistance: implications for vein graft failure.  Circ Res. 2002 Feb 8;90(2):205-12. PMID: 11834714
  23. Rosenfeld ME, Polinsky P, Virmani R, Kauser K, Rubanyi G, Schwartz SM. Advanced atherosclerotic lesions in the innominate artery of the ApoE knockout mouse.  Arterioscler Thromb Vasc Biol. 2000 Dec;20(12):2587-92.  PMID: 11116057
  24. Schneider DB, Vassalli G, Wen S, Driscoll RM, Sassani AB, DeYoung MB, Linnemann R, Virmani R, Dichek DA. Expression of Fas ligand in arteries of hypercholesterolemic rabbits accelerates atherosclerotic lesion formation.  Arterioscler Thromb Vasc Biol. 2000 Feb;20(2):298-308.  PMID: 10669624
  25. Moroi M, Zhang L, Yasuda T, Virmani R, Gold HK, Fishman MC, Huang PL. Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice.  J Clin Invest. 1998 Mar 15;101(6):1225-32.  PMID: 9502763
  26. Dunn PF, Newman KD, Jones M, Yamada I, Shayani V, Virmani R, Dichek DA. Seeding of vascular grafts with genetically modified endothelial cells. Secretion of recombinant TPA results in decreased seeded cell retention in vitro and in vivo.  Circulation. 1996 Apr 1;93(7):1439-46.  PMID: 8641034
  27. Rade JJ, Schulick AH, Virmani R, Dichek DA.  Local adenoviral-mediated expression of recombinant hirudin reduces neointima formation after arterial injury.  Nat Med. 1996 Mar;2(3):293-8.  PMID: 8612227
  28. Seidman JD, Berman JJ, Hitchcock CL, Becker RL Jr, Mergner W, Moore GW, Virmani R, Yetter RA. DNA analysis of cardiac myxomas: flow cytometry and image analysis.  Hum Pathol. 1991 May;22(5):494-500.  PMID: 2032696
  29. Kolodgie FD, Virmani R, Rice HE, Mergner WJ. Vascular reactivity during the progression of atherosclerotic plaque. A study in Watanabe heritable hyperlipidemic rabbits.  Circ Res. 1990 Apr;66(4):1112-26.  PMID: 2317889
  30. Rogan KM, Sears-Rogan P, Virmani R, Pyeritz RE. Familial myxomatous valvular disease.  Am J Cardiol. 1989 May 1;63(15):1149-51. No abstract available.   PMID: 2705389
  31. Cornel G, Sharratt GP, Virmani S, Rosales T, Lacson A. Familial coarctation of the aortic arch with bilateral ptosis: a new syndrome?  J Pediatr Surg. 1987 Aug;22(8):724-6.  PMID: 3656020
  32. Voss EG, Reddy CV, Detrano R, Virmani R, Zabriskie JB, Fotino M.  Familial dilated cardiomyopathy.  Am J Cardiol. 1984 Aug 1;54(3):456-7. No abstract available.   PMID: 6465036
  33. Virmani R, Robinowitz M, McAllister HA Jr. Nontraumatic death in joggers. A series of 30 patients at autopsy.  Am J Med. 1982 Jun;72(6):874-82.  PMID: 6211977